Buy B7-33 peptide online – 99% Purity
B7-33 Peptide is a synthetic, single-chain peptide derived from the B-chain of the naturally occurring human H2-relaxin hormone. Specifically, it is designed as a targeted agonist for the relaxing receptor RXFP1 and is extensively researched for its potent anti-fibrotic, anti-inflammatory, and cardiovascular protective properties.
Key Characteristics & Research Focus
Fibrosis and Organ Protection: Notably, B7-33 has been shown to reduce or reverse tissue scarring (fibrosis) in pre-clinical models of heart, kidney, and lung disease. Interestingly, its efficacy matches that of the full-length hormone.
Targeted Signaling Mechanism
Unlike full-length relaxin, B7-33 selectively activates the \(pERK\) pathway rather than the cAMP signaling cascade. This biased signaling is believed to provide the therapeutic benefits of relaxin while avoiding potentially unwanted systemic side effects, such as promoting prostate tumor growth.
Cardiovascular and Vasoprotective Effects
Moreover, studies in rodents indicate that B7-33 limits myocardial infarction (heart attack) damage, preserves cardiac function, and helps lower blood pressure. Additionally, its structure is a linear 27-amino-acid peptide (Sequence: H-VIKLSGRELVRAQIAISGMSTWSKRSL-OH), which lacks the disulfide bonds of the native protein. As a result, this simplifies synthesis and increases stability.
Primary Source & Further Studies
For foundational scientific data and ongoing research regarding B7-33’s pharmacology, you can review the initial development and characterization details published in the National Center for Biotechnology Information (NCBI). Ultimately, this resource will provide deeper insights into the potential applications and benefits of B7-33.
